BIOE 552: INTRO SYSTEMS BIOLOGY MODELING
Fall 2023 · Section 001 · CRN 14874
The course summarizes techniques for quantitative analysis and simulations of basic circuits in genetic regulation, signal transduction and metabolism. We discuss engineering approaches adapted to computational systems biology and aim to formulate evolutionary design principles explaining organization of networks in terms of their physiological demands. We discuss biochemical simulation methodology and software as well as recent advances in the field. Topics include end-product inhibition in biosynthesis, optimality and robustness of the signaling networks and kinetic proofreading. Same as 490 but with more emphasis on recent advances in the field - paper reading and presentations. Cross-list: BIOE 518, SSPB 502. Recommended Prerequisite(s): Basic knowledge of biochemistry, cell biology, linear algebra, and ordinary differential equations is expected. Mutually Exclusive: Cannot register for BIOE 552 if student has credit for BIOE 490.
- Credits
- 3
- Instructors
- Oleg Igoshin