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Department of Chemistry

Peter Wolynes

Bullard-Welch Foundation Professor of Chemistry

Professor of BioSciences, Materials Science & NanoEngineering, and Physics & Astronomy

Co-Director, Center for Theoretical Biological Physics

Member, Ken Kennedy Institute

The research in my group is broadly concerned with many-body phenomena in biology, chemistry and physics. A major theme is understanding systems where a large diversity of long-lived states is involved, necessitating the use of a statistical characterization of an energy or attractor landscape. The most notable examples are glasses, liquids, biomolecules and biomolecular regulatory networks. In the area of protein folding we are interested both in describing folding kinetics in the laboratory and the development of bioinformatically based schemes for predicting structure from sequence using computer simulation. A key concept is that the energy landscape of a foldable protein looks like a rugged funnel. This idea guides the development of both simple folding kinetics models and structure prediction algorithms. Similar issues of attractor landscapes also arise in higher order biological processes, such as gene recognition and genetic network regulation, which we also study. The energy landscapes of supercooled liquids and glasses also present interesting problems. We have shown how a new approach based on "random first order transitions" explains many quantitative relations found empirically both in liquids and under cryogenic conditions where quantum effects play a role. The same ideas show promise in the study of systems as different as high temperature superconductors, polymer assemblies, and microemulsions. They are also useful for describing the three-dimensional structure and dynamics of chromosomes and the interior of living cells.

Public Rice profile source

Average rating

3.4

15 temporary mock ratings

Difficulty

3.4

course-linked average

Courses

10

in seeded sections

Public profile

Biography

Peter Wolynes is the D.R. Bullard-Welch Foundation Professor of Science, with appointments in the departments of Chemistry, Physics and Astronomy, BioSciences and Materials Science and Engineering at Rice University. He graduated with an A.B. from Indiana University in 1971 and received a Ph.D. in Chemical Physics from Harvard University in 1976. He spent most of the year as a postdoctoral fellow with John Deutch at the Massachusetts Institute of Technology. He then spent from Fall 1976 to 1979 as an Assistant Professor in the Chemistry department at Harvard. In 1980 he moved to the University of Illinois, eventually becoming the Center for Advanced Study Professor of Chemistry, Physics and Biophysics. In 2000 he moved to the Department of Chemistry and Biochemistry at the University of California, San Diego. In 2011 he was named D.R. Bullard-Welch Foundation Professor of Science, with appointments in the departments of Chemistry, Physics, Biosciences and Materials Science and Engineering at Rice University in Houston, Texas. Professor Wolynes has been a visiting scholar for extended periods at the Max Planck Institute for Biophysical Chemistry, the Institute for Theoretical Physics (UCSB), the Institute for Molecular Science (Okazaki, Japan) and the Ecole Normale Superieure (Paris, France). He was a Fogarty Scholar-in-Residence at the National Institute of Health, Hinshelwood Lecturer at Oxford, and the Linnett Visiting Professor at Cambridge. Wolynes’s work across the spectrum of theoretical chemistry and biochemistry has been recognized by the 1986 ACS Award in Pure Chemistry, the 2000 Peter Debye Award for Physical Chemistry of the ACS, the Fresenius Award, the Joseph Hirschfelder Prize and the ACS Award in Theoretical Chemistry 2012. For his work on the energy landscape theory of protein folding he received the 2004 Biological Physics Prize from the American Physical Society (now called the Max Delbrück Prize) and the 2008 Founders Award of the Biophysical Society. He received an honorary Doctor of Science from Indiana University in 1988 and an honorary doctorate from Stockholm University in 2010. He was elected to both the National Academy of Sciences and the American Academy of Arts and Sciences in 1991. He is a fellow of the American Association for the Advancement of Science, the American Physical Society and the Biophysical Society. Wolynes has been elected to the American Philosophical Society, the German Academy of Sciences "Leopoldina," and as a Foreign Member to the Royal Society of London and the Indian National Science Academy. He was named an Einstein Chair Professor of the Chinese Academy of Sciences in 2010.

Research areas

Chemical Biology, Theoretical Chemistry, Chemistry of Life, Materials by Chemical Design

Keywords

Chemical Physics, glass transition, biomolecular dynamics

Courses taught

APPL 800

Research And Thesis

Thesis research under the supervision of faculty. Repeatable for Credit.

Applied PhysicsNone1-15 credits
3.59.5hAjayan, Pulickel, Alabastri, Alessandro, Azhang, Behnam, Bagchi, Kushal, Baraniuk, Richard G, Biswal, Sibani, Brake, Matthew, Bulchandani, Vir, Chan, Anthony, Chen, Songtao, Dai, Pengcheng, Grande-Allen, K. Jane, Gustavsson, Anna-Karin, Halas, Naomi, Han, Yimo, Huang, Shengxi, Hulet, Randy, Kampouri, Stavroula, Kemere, Caleb, Killian, Thomas, Kono, Junichiro, Lee, Hae Yeon, Luan, Lan, Ma, Xuedan, Marciel, Amanda, Martin, Lane, Mohite, Aditya, Morosan, Emilia, Naik, Gururaj, Natelson, Doug, Nordlander, Peter, Pagano, Guido, Patel, Ankit, Patel, Tirthak, Pu, Han, Raphael, Rob, Robinson, Jacob, Sabharwal, Ashutosh, Sempionatto Moreto, Juliane, Shah, Nishal, Shee, James, Si, Qimiao, Szablowski, Jerzy, Tang, Ming, Tkaczyk, Tomasz, Tour, James, Tringides, Christina, Veeraraghavan, Ashok, Verduzco, Rafael, Vlassakis, Julea, Wehmeyer, Geoff, Wittung Stafshede, Pernilla, Wolynes, Peter, Wong, Michael, Xie, Chong, Xie, Yonglong, Yi, Ming, Zhang, Yirui Arlene, Zhao, Yuji, Zhu, Hanyu

BIOS 310

Ind Res For Bios Undergrads

Independent research in Rice BioSciences faculty laboratories (sections 2 and above) or other Texas Medical Center laboratories (section 1). Students must have secured a research position prior to applying for BIOS 310. Students spend at least 42 hours in the laboratory for each semester hour of credit (>9h/week for 3 credits). A minimum of 3 credit hours is needed to count toward the BS in Biosciences or to replace one required 300+ level elective lab course for the BA in Biosciences (cannot replace major concentration core labs). Requires a proposal abstract, weekly reports, and a research paper (fall/spring/summer) or a poster presentation (spring/summer for advanced students). Students wishing to perform their research in an off-campus lab must apply online (biosugresearch.rice.edu) at least 3 weeks prior to the start of classes and may not register for fewer than 3 credit hours. Students taking BIOS 310 in the full summer semester must be available to do full-time research for a minimum of 6 weeks or part-time equivalent which should equal to a total of 126 hours working in the lab. It is recommended that summer students spread their hours over 8-10 weeks. Recommended Prerequisite(s): Students are strongly advised to secure research advisors and register for the class well in advance of the start of classes. Recommended Prerequisite(s): Students are strongly advised to secure research advisors and register for the class well in advance of the start of classes. Repeatable for Credit.

BiosciencesNone1-5 credits
4.06.7hAjo-Franklin, Caroline, An, Linna, Bartel, Bonnie, Bashor, Caleb, Beason-Abmayr, Beth, Bennett, Matthew, Braam, Janet, Carson, Daniel, Catanese, Jamie, Chappell, James, de Moraes, Marcos, Dunham, Amy, Egan, Scott, Evans, Kory, Flynn, Jonathan, Gao, Yang, Glasscock, Cameron, Gustin, Michael, Hennelly, Lauren, Hilton, Isaac, Iyer, Harini, Johnson, Cassidy, Kirienko, Natasha, Kranz, Sven, Lavery, Laura, Lieberman-Aiden, Erez, Loveless, Theresa, Lu, George, Lwigale, Peter, Masiello, Carrie, Matsuda, Seiichi P., McCary, Matt, McNew, James, Miller, Thomas, Nakhleh, Luay, Nikonowicz, Edward, Novak, Joseph, Olmos, Joey, Onuchic, Jose, Rudolf, Volker, Rummel, Andrea, Segatori, Laura, Shamoo, Yousif, Siemann, Evan, Silberg, Joff, Solomon, Scott, Stewart, Charles, Tabor, Jeffrey, Tao, Yizhi, Uribe, Rosa, Wagner, Daniel, Wittung Stafshede, Pernilla, Wolynes, Peter, Xiao, Han

BIOS 401

Undergraduate Honors Research

The Biosciences Honors Research Program offers our seniors and advanced juniors the opportunity to perform a two-semester, individual research project in a research laboratory in Biosciences or an approved off-campus site and offers opportunities for students to develop their written and oral scientific communication skills. Students registering for BIOS 401 are expected to take BIOS 402 the following semester. Each semester, students are expected to average 15 hours per week in research (laboratory) and communication skills activities (scheduled through the companion seminar co-requisite). In BIOS 401, students will prepare regular progress reports, attend lab meetings, and write an end-of-semester short paper (at least 5 pages) on their work. Must register for co-requisite BIOS 411.

BiosciencesNone5 credits
3.89.8hAjo-Franklin, Caroline, An, Linna, Bartel, Bonnie, Beason-Abmayr, Beth, Bennett, Matthew, Braam, Janet, Carson, Daniel, Catanese, Jamie, Chappell, James, de Moraes, Marcos, Dunham, Amy, Egan, Scott, Evans, Kory, Gao, Yang, Gustin, Michael, Hennelly, Lauren, Kirienko, Natasha, Lavery, Laura, Lieberman-Aiden, Erez, Loveless, Theresa, Lwigale, Peter, Matsuda, Seiichi P., McCary, Matt, McNew, James, Miller, Thomas, Nakhleh, Luay, Nikonowicz, Edward, Onuchic, Jose, Rudolf, Volker, Rummel, Andrea, Segatori, Laura, Shamoo, Yousif, Siemann, Evan, Silberg, Joff, Solomon, Scott, Stewart, Charles, Tabor, Jeffrey, Tao, Yizhi, Uribe, Rosa, Wagner, Daniel, Wittung Stafshede, Pernilla, Wolynes, Peter, Xiao, Han

BIOS 611

Research Seminar

Discussion of individual research or current topics in particular areas. Intended for students conducting research projects in the lab of the instructor. Repeatable for Credit.

BiosciencesNone1 credits
3.98.2hAjo-Franklin, Caroline, An, Linna, Bartel, Bonnie, Bashor, Caleb, Bennett, Matthew, Braam, Janet, Carson, Daniel, Chappell, James, de Moraes, Marcos, Gao, Yang, Glasscock, Cameron, Gustin, Michael, Han, Yimo, Hilton, Isaac, Iyer, Harini, Kirienko, Natasha, Lavery, Laura, Lieberman-Aiden, Erez, Loveless, Theresa, Luan, Lan, Lwigale, Peter, Matsuda, Seiichi P., McNew, James, Nikonowicz, Edward, Onuchic, Jose, Rosenberg, Susan, Sawakuchi, Gabriel, Segatori, Laura, Shamoo, Yousif, Silberg, Joff, Stewart, Charles, Tao, Yizhi, Uribe, Rosa, Wagner, Daniel, Wittung Stafshede, Pernilla, Wolynes, Peter, Xiao, Han, Zhou, Zheng

BIOS 800

Bcb Graduate Research

Biochemistry & Cell Biology graduate research. Repeatable for Credit.

BiosciencesNone1-15 credits
3.96.1hAjo-Franklin, Caroline, An, Linna, Bartel, Bonnie, Bashor, Caleb, Bennett, Matthew, Braam, Janet, Carson, Daniel, Chappell, James, de Moraes, Marcos, Gao, Yang, Glasscock, Cameron, Gustin, Michael, Han, Yimo, Hilton, Isaac, Iyer, Harini, Kirienko, Natasha, Lavery, Laura, Lieberman-Aiden, Erez, Loveless, Theresa, Luan, Lan, Lwigale, Peter, Matsuda, Seiichi P., McNew, James, Nikonowicz, Edward, Onuchic, Jose, Rosenberg, Susan, Sawakuchi, Gabriel, Segatori, Laura, Shamoo, Yousif, Silberg, Joff, Stewart, Charles, Tao, Yizhi, Uribe, Rosa, Wagner, Daniel, Wittung Stafshede, Pernilla, Wolynes, Peter, Xiao, Han, Zhou, Zheng

CHEM 415

Chemical Kinetics & Dynamics

Description and analysis of the rates of unimolecular, bimolecular and composite chemical reactions in gas and solution phases. Both macroscopic kinetics and microscopic reaction dynamics are covered. Cross-list: CHEM 515. Mutually Exclusive: Cannot register for CHEM 415 if student has credit for CHEM 515.

ChemistryNone3 credits
3.39.4hWolynes, Peter

CHEM 515

Chemical Kinetics & Dynamics

Description and analysis of the rates of unimolecular, bimolecular, and composite chemical reactions in gas and solution phases. Both macroscopic kinetics and microscopic reaction dynamics are covered. Cross-list: CHEM 415. Mutually Exclusive: Cannot register for CHEM 515 if student has credit for CHEM 415.

ChemistryNone3 credits
3.87.9hWolynes, Peter

CHEM 800

Graduate Research

Repeatable for Credit.

ChemistryNone1-15 credits
3.97.7hAjayan, Pulickel, Alvarez, Pedro, Bagchi, Kushal, Ball, Zachary, Bao, Gang, Dai, Mingjie, Diehl, Michael, Gustavsson, Anna-Karin, Hafner, Jason, Halas, Naomi, Han, Yimo, Hartgerink, Jeffrey, Hernandez Sanchez, Raul, Hulet, Randy, Igoshin, Oleg, Jones, Matt, Kampouri, Stavroula, Kolomeisky, Anatoly, Kurti, Laszlo, Lou, Jun, Ma, Yuan, MacKintosh, Frederick, Marciel, Amanda, Marti-Arbona, Angel, Martin, Lane, Masiello, Carrie, Matsuda, Seiichi P., McHugh, Kevin, Mikos, Antonios, Mohite, Aditya, Morosan, Emilia, Mou, Quanbing, Nevidomskyy, Andriy, Nienhaus, Lea, Nordlander, Peter, Onuchic, Jose, Pasquali, Matteo, Renata, Hans, Sarlah, David, Scuseria, Gustavo, Shee, James, Tour, James, Wang, Haotian, Weisman, Bruce, West, Julian, Wittung Stafshede, Pernilla, Wolynes, Peter, Wong, Michael, Xiao, Han, Yakobson, Boris, Yruegas, Samantha

PHYS 800

Graduate Research

Thesis research under the supervision of department faculty. Repeatable for Credit.

PhysicsNone1-15 credits
3.68.7hAcosta, Darin, Alexander, David, Amin, Mustafa, Baring, Matthew, Bradshaw, Stephen, Bulchandani, Vir, Chan, Anthony, Chia, Nai-Hui, Dai, Pengcheng, Dunning, Barry, Ecklund, Karl, Foster, Matthew, Geurts, Frank, Hafner, Jason, Halas, Naomi, Hartigan, Patrick, Hautier, Geoffroy, Hazzard, Kaden, Higuera Pichardo, Aaron, Hulet, Randy, Isella, Andrea, Jo, Gyu-Boong, Johns-Krull, Christopher, Kiang, Ching-Hwa, Killian, Thomas, Kolomeisky, Anatoly, Kono, Junichiro, Li, Wei, Liang, Edison, Long, Andrew, MacKintosh, Frederick, Morosan, Emilia, Natelson, Doug, Nevidomskyy, Andriy, Nienhaus, Lea, Nordlander, Peter, Onuchic, Jose, Padley, Paul, Pagano, Guido, Pirie, Harris, Pu, Han, Reiff, Pat, Reiter, Megan, Scuseria, Gustavo, Si, Qimiao, Tang, Evelyn, Toffoletto, Frank, Tunnell, Chris, Wolynes, Peter, Xie, Yonglong, Yakobson, Boris, Yepes, Pablo, Yi, Ming

SSPB 800

Graduate Research

Graduate students will conduct independent research/thesis project under the direction of their advisor. Repeatable for Credit.

Systems/Synthetic/Phys BiologyNone1-15 credits
3.35.8hAjo-Franklin, Caroline, Alvarez, Pedro, An, Linna, Bao, Gang, Bashor, Caleb, Bennett, Matthew, Butts, Jessica, Chappell, James, Dai, Mingjie, de Moraes, Marcos, Diehl, Michael, Gao, Yang, Glasscock, Cameron, Gollihar, Jimmy, Gustavsson, Anna-Karin, Hilton, Isaac, Igoshin, Oleg, Iyer, Harini, Kalluri, Raghu, Kavraki, Lydia, Kiang, Ching-Hwa, Kimmel, Marek, Kirienko, Natasha, Kolomeisky, Anatoly, Lavery, Laura, Li, Lei, Lieberman-Aiden, Erez, Loveless, Theresa, Lu, George, Luan, Lan, Ma, Yuan, MacKintosh, Frederick, Masiello, Carrie, Mou, Quanbing, Nakhleh, Luay, Nikonowicz, Edward, Onuchic, Jose, Phillips, George, Raphael, Rob, Renata, Hans, Robinson, Jacob, Segatori, Laura, Shamoo, Yousif, Silberg, Joff, St. Pierre, Francois, Stadler, Lauren, Szablowski, Jerzy, Tabor, Jeffrey, Tang, Evelyn, Tao, Yizhi, Thyer, Ross, Treangen, Todd, Uribe, Rosa, Veiseh, Omid, Vlassakis, Julea, Warmflash, Aryeh, Wolynes, Peter, Xiao, Han, Xie, Chong, Yao, Vicky

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